Receptor mediated disruption of the smooth muscle SR buffer barrier function
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چکیده
منابع مشابه
MUSCARINIC RECEPTOR SUBTYPES IN SMOOTH MUSCLE FROM THE BODY OF HUMAN STOMACH
Up to date, there are four pharmacologically characterized subtypes of muscarinic receptors (M1, M2, M3 and M4). In our study we have investigated muscarinic receptor subtypes in smooth muscle layers of human stomach. Isolated preparations of longitudinal and circular muscle layers from human stomach were used. Acetylcholine, bethanechol, carbachol, pilocarpine and AHR -602 produced concen...
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Janssen, Luke J., Pierre A. Betti, Stuart J. Netherton, and Denise K. Walters. Superficial buffer barrier and preferentially directed release of Ca21 in canine airway smooth muscle. Am. J. Physiol. 276 (Lung Cell. Mol. Physiol. 20): L744–L753, 1999.—We examined cytosolic concentration of Ca21 ([Ca]i) in canine airway smooth muscle using fura 2 fluorimetry (global changes in [Ca]i), membrane cur...
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We examined cytosolic concentration of Ca2+([Ca2+]i) in canine airway smooth muscle using fura 2 fluorimetry (global changes in [Ca2+]i), membrane currents (subsarcolemmal [Ca2+]i), and contractions (deep cytosolic [Ca2+]i). Acetylcholine (10-4 M) elicited fluorimetric, electrophysiological, and mechanical responses. Caffeine (5 mM), ryanodine (0.1-30 μM), and 4-chloro-3-ethylphenol (0.1-0.3 mM...
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In healthy coronary smooth muscle cells, the superficial sarcoplasmic reticulum (SR) buffers rise in intracellular Ca(2+) levels. In diabetic dyslipidemia, basal Ca(2+) levels are increased, yet Ca(2+) influx is decreased and SR Ca(2+) uptake is increased. Exercise prevents diabetic dyslipidemia-induced increases in basal Ca(2+) levels and decreases in Ca(2+) influx. We tested the hypothesis th...
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Tachykinins are present in enteric nerves of the gastrointestinal tract and cause contraction of esophageal smooth muscle; however, the mechanisms involved are not understood. Our aim was to characterize tachykinin signaling in human esophageal smooth muscle. We investigated functional effects of tachykinins on human esophageal smooth muscle using tension recordings and isolated cells, receptor...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1992
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)59895-x